Pavlin’s Lab is an interdisciplinary research within Institute of Biophysics, Faculty of Medicine, University of Ljubljana. The Institute of Biophysics has a long tradition of excellent interdisciplinary research in the field of biophysics and biomedicine.
The research work of the group includes different areas of biomedicine, biophysics, and nanobiotechnology .
The main areas of research are:
- The research of cellular metabolic pathways of immune cells immunometabolism and cancer metabolism. Targeting of metabolic pathways enables possibility to improve T cells properties in the context of immune checkpoint inhibitors and CAR T therapy. In parallel we explore alterations in metabolic pathways in relation to metastatic process and adaptations during anchorage independent growth.
- Advance drug delivery using electroporation method – gene electrotransfer in vitro and in 3D in vitro tissue models, delivery of small molecules, DNA and short RNAi into various mammalian, tumour and primary human cells.
- Immunotoxicity of nanomaterials and development of nanoparticles for cell labelling and drug delivery.
The members of the group have track record and are cited across different fields from biomedicine, biophysics, biotechnology to material sciences . Collaboration with complementary research groups in Slovenia and abroad enables efficient translation of the research results into clinical and industrial setting.
